论文发表 论文发表

最小化 最大化

期刊封面：

        

发表论文：

【2025】

49. Yang C., Meng J., Li W., Zhao Y., Li J., Wen Y., Liu S., Cheng X., Mi S., Huo H., Lu X.*, Gao M.* "Iron Oxide Nanoparticles Activate Innate Immunity Through Toll-Like Receptors and Cooperate with CpG as a Potent Nano-Adjuvant" Small 2025, e08378.

48. Zhao Z., Shan X., Ding J.*, Ma B., Li B., Huang W., Yang Q., Fang Y., Chen J., Song C., Wei C., Liu S., Cheng X., Zhang S., Liu Y., Wu H., Luo C., Shu S., Qiao X., Wang Z.*, Lu X.*, Miao L.* "Boosting RNA nanotherapeutics with V-ATPase activating non-inflammatory lipid nanoparticles to treat chronic lung injury" Nature Communication 2025, 16, 6477.

47. Chang T., Zheng Y., Jiang M., Jia S., Bai J., Zheng Z., Li S., Guo J., Wang Y., Wang Y., Liu H., Liu J., Ni L., Cheng X., Liu S., Zhang H., Pi W., Lin F., Liu S., Wang W., Wang G., Wang L., Miao L., Lu X., Deng Z., Bai B., Qin Z., Gao H.*, Shao Y.* "Peptide codes for organ-selective mRNA delivery" Nature Material 2025. 

46. Zhang Y., Zhang L., Gao H., Du S., Chen Q., Lu X.*, Lin J.* "Multi-functional lipid nanoformulations for enhancing the efficacy of mRNA tumor vaccines by reversing tumor immunosuppressive microenvironment" Nano Today 2025, 63, 102757.

45.Cheng, X.; Zheng, X.; Tao, K.; Huo, H.; Liu, Z.*; Lu, X.*; Wang, J*.; "Freezing induced incorporation of betaine in lipid nanoparticles enhances mRNA delivery" Nature Communications, 2025, 16, 4700

44. Yang, C.; Ma, H.; Meng, J.; Li, J.; Huo, H.; Li, W.; Zhao, Y.; Wen, Y.; Mi, S.; Liu, S.; Cheng, X.; Zu, H.; Sun, S.; Ye, L.; Wang, H.; He, Y.*; Lu, X.*; Gao, M.* "Direct cGAMP Delivery via Iron Oxide Nanoparticles for Enhanced STING Activation and Durable Antitumor Immunity". Nano Letters, 2025, 25, 7577–7586.

【2024】

43. Shan, X.;Zhao, Z.;Lai, P.;Liu, Y.;Li, B.;Ke, Y.;Jiang, H.;Zhou, Y.;Li, W.;Wang, Q.;Qin, P.;Xue, Y.;Zhang, Z.;Wei, C.;Ma, B.;Liu, W.;Luo, C.;Lu, X.;Lin, J.;Shu, L.;Jie, Y.;Xian, X.;Delcassian, D.;Ge, Y.; Miao, L.*; "RNA nanotherapeutics with fibrosis overexpression and retention for MASH treatment". Nature Communications, 2024, 15, 7263.

42. Liu, S.;Wen, Y.;Shan, X.;Ma, X.;Yang, C.;Cheng, X.;Zhao, Y.;Li, J.;Mi, S.;Huo, H.;Li, W.;Jiang, Z.;Li, Y.;Lin, J.;Miao, L.;  Lu, X.*; "Charge-assisted stabilization of lipid nanoparticles enables inhaled mRNA delivery for mucosal vaccination". Nature Communications, 2024, 15, 9471.

41.Li, J.;Hu, J.;Jin, D.;Huo, H.;Chen, N.*;Lin, J.*; Lu, X.*; "High-throughput synthesis and optimization of ionizable lipids through A3 coupling for efficient mRNA delivery". Journal of Nanobiotechnology, 2024, 22, 672.

40. Li, W.; Li, Y.; Li, J.; Meng, J.; Jiang, Z.; Yang, C.; Wen, Y.; Liu, S.; Cheng, X.; Mi, S.; Zhao, Y.; Miao, L.*; Lu. X.*;  "All-Trans-Retinoic Acid-Adjuvanted mRNA Vaccine Induces Mucosal Anti-Tumor Immune Responses for Treating Colorectal Cancer" Advanced Science, 2024, 11 (22), 2309770.

39. Mi, S.; Li, W.; Wen, Y.; Yang, C.; Liu, S.; Li, J.; Cheng, X.; Zhao, Y.; Huo, H.; Zu, H.; Lu. X.*; "Layer-by-layer nanoparticle encapsulating all-trans retinoic acid and CpG as a mucosal adjuvant targeting colorectal cancer" Biomaterials Science, 2024, 12 (9), 2292-2301.

38. Wang, X.; Wen, Y.; Wang. Y.*; Li, W.; Lu. X.*; You. W.*; "7-Oxa-2, 3-Diazanorbornene: A One-Step Accessible Monomer for Living Ring-Opening Metathesis Polymerization to Produce Backbone-Biodegradable Polymers" CCS Chemistry, 2024.

37. Zhao, Y.†; Liu, S.†; Lu. X.* "Advances in Pulmonary Protein Delivery Systems" Adv. Nanobiomed. Res., 2024, 2300176.

【2023】

36. Cheng, X. †; Liu, S. †; Sun, J. †; Liu, L.; Ma, X.; Li, J.; Fan, B.; Yang, C.; Zhao, Y.; Liu, S.; Wen, Y.; Li, W.; Sun, S.; Mi, S.; Huo, H.; Miao, L.; Pan, H.; Cui, X.*; Lin, J.*; Lu. X*. "A Synergistic Lipid Nanoparticle Encapsulating mRNA Shingles Vaccine Induces Potent Immune Responses and Protects Guinea Pigs from Viral Challenges" Adv. Mater., 2023, 2310886.

35. Zhao, Y.; Cheng, X.; Li, J.; Liu, S.; Meng, J.; Li, W.; Yang, C.; Wen, Y.; Mi, S.; Huo, H.; Xu, H.; Lu. X.* "Pulmonary delivery of immune checkpoint inhibitors using a responsive polyethylene glycol nanogel for treating lung metastasis" Nano Today, 2023, 52, 101988.

34. Huo, H.†; Cheng, X.†; Xu, J.; Lin, J.*; Chen, N.*; Lu. X.* "A fluorinated ionizable lipid improves the mRNA delivery efficiency of lipid nanoparticles" J. Mater. Chem. B., 2023, 11, 4171. (当期封面文章，热点文章).

33. Liu, S.; Sun, X.; Lu. H.; Chen, D.; Li, X.; Li, L.; Su, S.; Zhao, Z.; Cao, X.; Liu, L.; Lai, L.; Lu, X.; Shu, C.; Wang, C.; Bai. C. "Fullerene-based nanocomplex assists pulmonary delivery of siRNA for treating metastatic lung cancer" Nano Today, 2023, 50, 101878.

32. Wei, X.; Li, Y.; Cheng, X.; Wen, Y.; Yuan, W.; Chen, R.; Meng, S.; Lu. X.; Yu, Z.; Xu. L.; Liu, D.; Dong, Y.* "Increase Nebulization Stability of Lipid Nanoparticles by Integrating a DNA Supramolecular Hydrogel" ACS Macro Lett., 2023, 12, 745.

【2022】

31. Sadeghi, I.; Lu, X; Sarmadi, M.; Langer, R.; Jaklene, A.*; "Micromolding of thermoplastic polymers for direct fabrication of discrete, multilayered microparticles" Small Methods, 2022, 2200232.

30. Di, Z.; Lu, X; Zhao, J.; Jaklene, A.; Zhao Y.; Langer, R.; Li, L.*; "Mild acidosis-directed signal amplification in tumor microenviroment via spatioselective recruitment of DNA amplifiers" Angew. Chem. Int. Ed., 2022, e202205436.

29. Meng, J.†; Zhang, P†; Chen, Q.; Wang, Z.; Gu, Y.; Ma, J.; Li, W.; Yang, C.; Qiao, Y.; Hou, Y.; Jing, L.; Wang, Y.; Gu, Z.; Zhu, L.; Xu, H.; Lu, X.*; Gao, M.*; "Two-pronged intracellular co-delivery of antigen and adjuvant for synergistic cancer immunotherapy" Adv. Mater., 2022, 2202168.

28. Li, W.†; Meng, J.†; Ma, X.; Lin, J.*; Lu, X.*, Advanced materials for the delivery of vaccines for infectious diseases, Biosafety and Health, 2022, https://doi.org/10.1016/j.bsheal.2022.03.002

27. Deng, B.; Ma, B.; Ma, Y.; Cao, P.; Leng, X.; Huang, P.; Zhao, Y.; Ji, T.; Lu, X.*; Liu, L.*, Doxorubicin and CpG loaded liposomal spherical nucleic acid for enhanced Cancer treatment, J. Nanobiotechnol., 2022, 20, 140.

26. Yu, Y.†; Li, J.†; Song, B.†; Ma, Z.; Zhang, Y.; Sun, H.; Wei, X.; Bai, Y.; Lu, X.; Zhang, P.*; Zhang, X*. Polymeric PD-L1 blockade nanoparticles for cancer photothermal-immunotherapy, Biomaterials, 2022, 280, 121312.

【2021】

25. Jia, F.†; Chen, P.†; Wang, D.; Sun, Y.; Ren, M.; Wang, Y.; Cao, X.; Zhang, L.; Fang, Y.; Tan, X.; Lu, H.; Cai, J.; Lu, X.*; Zhang, K*. Bottlebrush Polymer- Conjugated Melittin Exhibits Enhanced Antitumor Activity and Better Safety Profile, ACS Appl. Mater. Interfaces, 2021. DOI: 10.1021/acsami. 1c 14285.

24. Fang, Y.;Lu, X.; Wang, D.; Cai, J.; Wang, Y.; Chen, P.; Ren, M.; Lu, H.; Union, J.; Zhang, L.; Sun, Y.; Jia, F.; Kang, X.; Tan, X.; Zhang, K.* Spherical Nucleic Acids for Topical Treatment of Hyperpigmentation, J. Am. Chem. Soc. 2021, 143, 1296-1300.

【2020】

23. Lu, X.†; Miao, L.†; Gao, W.; Chen, Z.; McHugh, K.; Sun, Y.; Tochka, Z.; Tomasic, S.; Sadtler, K.; Hyacinthe, A.; Huang, Y.; Graf, T.; Hu, Q.; Sarmadi, M.; Langer, R.*; Anderson, D.*; Jaklenec, A*. Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy. Sci. Transl. Med. 2020, 12, eaaz6606.

22. Lu, X.†; Fu, H.†; Shih, K.-C.; Jia, F.; Sun, Y.; Wang, D.; Wang, Y.; Ekatan, S.; Nieh, M.-P.*; Lin, Y.*; Zhang, K.* DNA-mediated step-growth polymerization of bottlebrush macromonomers. J. Am. Chem. Soc. 2020, 142, 10297-10301.

21. Sarmadi, M.; Behrens, A.; McHugh, K.; Contreras, H.; Tochka, Z.; Lu, X.; Langer, R.*; Jaklenec, A.* Modeling, design, and machine learning-based framework for optimal injectability of microparticle-based drug formulations. Sci. Adv. 2020, 6, eabb6594.

【2019】

20. Wang, D.; Lin, J.; Jia, F.; Tan, X.; Wang, Y.; Sun, X.; Cao, X.; Che, F.; Lu, H.; Gao, X.; Shimkonis, J.C.; Nyoni, Z.; Lu, X.*; Zhang, K.* Bottlebrush-architectured poly (ethylene glycol) as an efficient vector for RNA interference in vivo. Sci. Adv. 2019, 5, eaav9322.

19. Anselmo, A.C.*; Xu, X.*; Buerkli, S.*; Zeng, Y.; Tang, W.; McHugh, K.J.; Behrens, A.M.; Rosenberg, E.; Duan, A.R.; Sugarman, J.L.; Zhuang, J.; Collins, J.; Lu, X.; Graf, T.; Tzeng, S.Y.; Rose, S.; Acolatse, S.; Nguyen, T.D.; Le, X.; Guerra, A.S.; Freed, L.E.; Weinstock, S.B.; Sears, C.B.; Nikolic, B.; Wood, L.; Welkhoff, P.A.; Oxley, J.D.; Moretti, D.; Zimmermann, M.B.; Langer, R.**; Jaklenec, A.** A heat-stable microparticle platform for oral micronutrient delivery. Sci. Transl. Med. 2019, 11, eaaw3680.

【2018】

18. Lu, X.; Zhang, K.* PEGylation of therapeutic oligonucleotides: From linear to highly branched PEG architectures. Nano, Res. 2018, 11, 5519-5534.

17. Li, Z.; Behrens, A.M.; Ginat, N.; Tzeng, S.Y.; Lu, X.; Sivan, S.; Langer, R.*; Jaklenec, A.* Biofilm-inspired encapsulation of probiotics for the treatment of complex infections. Adv. Mater. 2018, 1803925.

16. Li, H.; Zhang, B.;Lu, X.; Tan, X.; Jia, F.; Xiao, Y.; Cheng, Z.; Li, Y.; Sliva, D.O.; Schrekker, H.S.; Zhang, K.; Mirkin, C.A. Molecular spherical nucleic acids. P. Natl. Acad. Sci. USA 2018, 115, 4340-4344.

15. Jia, F.; Wang, D.; Lu, X.; Tan, X.; Wang, Y.; Lu, H.; Zhang, K. Improving the enzymatic stability and the pharmacokinetics of oligonucleotides via DNA-backboned bottlebrush polymers. Nano Lett. 2018, 18, 7378-7382.

【2017年及以前】

14. Cao, X.†; Lu, X.†; Wang, D.; Jia, F.; Tan, X.; Corley, M.; Chen, X.; Zhang, K.* Modulating the cellular immune response of oligonucleotides by brush polymer-assisted compaction. Small 2017, 13, 1701432.

13. Wang, D.;Lu, X.; Jia, F.; Tan, X.; Sun, X.; Cao, X.; Wai, F.; Zhang, C.*; Zhang, K.* Precision Tuning of DNA-and  poly(ethylene glycol)-based nanoparticles via co-assembly  for effective antisense gene regulation. Chem. Mater. 2017, 29, 9882-9886.

12. Jia, F.; Lu, X.; Wang, D.; Cao, X.; Tan, X.; Lu, H.; Zhang, K.* Depth-profiling the nuclease stability and the gene silencing efficacy of  brush-architectured poly 

 (ethylene glycol)-DNA conjugates. J. Am. Chem. Soc. 2017, 139, 10605-10608.

11. Jia, F.; Lu, X.; Tan, X.; Wang, D.; Cao, X.; Zhang, K.* Effect of PEG Architecture on the hybridization thermodynamics and protein accessibility of PEGylated oligonucleotides. Angew. Chem. Int. Ed. 2017, 56, 1239-1243.

10. Cressiot, B.; Greive, S.J.; Si, W.; Pascoa, T.; Mojtabavi, M.; Chechik, M.; Jenkins, H.T.; Lu, X.; Zhang, K.; Aksimentiev, A.*; Antson, A.A.*; Wanunu, M.* Porphyrin-Assisted docking of a thermophage portal protein into lipid bilayers:  nanopore engineering and  characterization. ACS Nano 2017, 11, 11931-11945.

9. Antczak, N.M.; Packer, M.R.; Lu, X.; Zhang, K.; Beuning, P.J.* Human Y-family DNA polymerase kappa is more tolerant to changes in its active site loop than its ortholog Escherichia coli Dinb.Chem. Res. Toxicaol. 2017, 30, 2002-2012.

8. Tan, X.; Lu, X.; Jia, F.; Liu, X.; Sun, Y.; Logan, J.K.; Zhang, K.* Blurring the role of oligonucleotides: spherical nucleic acids as a drug delivery vehicle. J. Am. Chem. Soc. 2016, 138, 10834-10837.

7.  Lu, X.; Jia, F.; Tan, X.; Wang, D.; Cao, X.; Zheng, J.; Zhang, K.* Effective antisense gene regulation via non-cationic, polyethylene glycol brushes.J. Am. Chem. Soc. 2016, 138, 9097-9100.

6. Lu, X.; Tran, T.H.; Jia, F.; Tan, X.; Davis, S.; Krishnan, S.; Amiji, M.M.; Zhang, K.* Providing oligonucleotides with steric selectivity by brush polymer-assisted compaction. J. Am. Chem. Soc. 2015, 137, 12466-12469.

5. Tan, X.; Li, B.B.; Lu, X.; Jia, F.; Santori, C.; Menon, P.; Li, H.; Zhang, B.; Zhao, J.J; Zhang, K.* Light-triggered, self-immolative nucleic acid-drug nanostructures.J. Am. Chem. Soc. 2015, 137, 6112-6115.

4. Nevin, P.;Lu, X.; Zhang, K.; Engen, J.; Beuning, P. Non-cognate DNA damage prevents formation of active conformation of Y-family DNA polymerases DinB and pol kappa. Faseb J. 2015, 29, 2646.

3. Jia, F.;Lu, X.; Tan, X.; Zhang, K.* Facile synthesis of nucleic acid-polymer amphiphiles and their self-assembly. Chem. Commun. 2015, 51, 7843-7846.

2. Lu, X.; Watts, E.; Jia, F.; Tan, X.; Zhang, K.* Polycondensation of polymer brushes via DNA hybridization. J. Am. Chem. Soc. 2014, 136, 10214-10217.

1. Lu, X.; Xu, J.* Negative ion mass spectral fragmentation of N-alkoxycarbonyl-1-aminoarylmethyl phosphonic monoesters under electrospray ionization conditions. Phosphorus, Sulfur, Silicon Relat. Elem. 2012, 187, 1151-1160.