Publications Publications

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Papers：

【2024】

40. Li, W.; Li, Y.; Li, J.; Meng, J.; Jiang, Z.; Yang, C.; Wen, Y.; Liu, S.; Cheng, X.; Mi, S.; Zhao, Y.; Miao, L.*; Lu. X.*;  "All-Trans-Retinoic Acid-Adjuvanted mRNA Vaccine Induces Mucosal Anti-Tumor Immune Responses for Treating Colorectal Cancer" Advanced Science, 2024, 11 (22), 2309770.

39. Mi, S.; Li, W.; Wen, Y.; Yang, C.; Liu, S.; Li, J.; Cheng, X.; Zhao, Y.; Huo, H.; Zu, H.; Lu. X.*; "Layer-by-layer nanoparticle encapsulating all-trans retinoic acid and CpG as a mucosal adjuvant targeting colorectal cancer" Biomaterials Science, 2024, 12 (9), 2292-2301.

38. Wang, X.; Wen, Y.; Wang. Y.*; Li, W.; Lu. X.*; You. W.*; "7-Oxa-2, 3-Diazanorbornene: A One-Step Accessible Monomer for Living Ring-Opening Metathesis Polymerization to Produce Backbone-Biodegradable Polymers" CCS Chemistry, 2024, https://doi.org/10.31635/ccschem.024.202303697.

37. Zhao, Y.†; Liu, S.†; Lu. X.* "Advances in Pulmonary Protein Delivery Systems" Adv. Nanobiomed. Res., 2024, 2300176.

【2023】

36. Cheng, X. †; Liu, S. †; Sun, J. †; Liu, L.; Ma, X.; Li, J.; Fan, B.; Yang, C.; Zhao, Y.; Liu, S.; Wen, Y.; Li, W.; Sun, S.; Mi, S.; Huo, H.; Miao, L.; Pan, H.; Cui, X.*; Lin, J.*; Lu. X*. "A Synergistic Lipid Nanoparticle Encapsulating mRNA Shingles Vaccine Induces Potent Immune Responses and Protects Guinea Pigs from Viral Challenges" Adv. Mater., 2023, 2310886.

35. Zhao, Y.; Cheng, X.; Li, J.; Liu, S.; Meng, J.; Li, W.; Yang, C.; Wen, Y.; Mi, S.; Huo, H.; Xu, H.; Lu. X.* "Pulmonary delivery of immune checkpoint inhibitors using a responsive polyethylene glycol nanogel for treating lung metastasis" Nano Today, 2023, 52, 101988.

34. Huo, H.†; Cheng, X.†; Xu, J.; Lin, J.*; Chen, N.*; Lu. X.* "A fluorinated ionizable lipid improves the mRNA delivery efficiency of lipid nanoparticles" J. Mater. Chem. B., 2023, 11, 4171. (当期封面文章，热点文章).

33. Liu, S.; Sun, X.; Lu. H.; Chen, D.; Li, X.; Li, L.; Su, S.; Zhao, Z.; Cao, X.; Liu, L.; Lai, L.; Lu, X.; Shu, C.; Wang, C.; Bai. C. "Fullerene-based nanocomplex assists pulmonary delivery of siRNA for treating metastatic lung cancer" Nano Today, 2023, 50, 101878.

32. Wei, X.; Li, Y.; Cheng, X.; Wen, Y.; Yuan, W.; Chen, R.; Meng, S.; Lu. X.; Yu, Z.; Xu. L.; Liu, D.; Dong, Y.* "Increase Nebulization Stability of Lipid Nanoparticles by Integrating a DNA Supramolecular Hydrogel" ACS Macro Lett., 2023, 12, 745.

【2022】

31. Sadeghi, I.; Lu, X; Sarmadi, M.; Langer, R.; Jaklene, A.*; "Micromolding of thermoplastic polymers for direct fabrication of discrete, multilayered microparticles" Small Methods, 2022, 2200232.

30. Di, Z.; Lu, X; Zhao, J.; Jaklene, A.; Zhao Y.; Langer, R.; Li, L.*; "Mild acidosis-directed signal amplification in tumor microenviroment via spatioselective recruitment of DNA amplifiers" Angew. Chem. Int. Ed., 2022, e202205436.

29. Meng, J.†; Zhang, P†; Chen, Q.; Wang, Z.; Gu, Y.; Ma, J.; Li, W.; Yang, C.; Qiao, Y.; Hou, Y.; Jing, L.; Wang, Y.; Gu, Z.; Zhu, L.; Xu, H.; Lu, X.*; Gao, M.*; "Two-pronged intracellular co-delivery of antigen and adjuvant for synergistic cancer immunotherapy" Adv. Mater., 2022, 2202168.

28. Li, W.†; Meng, J.†; Ma, X.; Lin, J.*; Lu, X.*, Advanced materials for the delivery of vaccines for infectious diseases, Biosafety and Health, 2022, https://doi.org/10.1016/j.bsheal.2022.03.002

27. Deng, B.; Ma, B.; Ma, Y.; Cao, P.; Leng, X.; Huang, P.; Zhao, Y.; Ji, T.; Lu, X.*; Liu, L.*, Doxorubicin and CpG loaded liposomal spherical nucleic acid for enhanced Cancer treatment, J. Nanobiotechnol., 2022, 20, 140.

26. Yu, Y.†; Li, J.†; Song, B.†; Ma, Z.; Zhang, Y.; Sun, H.; Wei, X.; Bai, Y.; Lu, X.; Zhang, P.*; Zhang, X*. Polymeric PD-L1 blockade nanoparticles for cancer photothermal-immunotherapy, Biomaterials, 2022, 280, 121312.

【2021】

25. Jia, F.†; Chen, P.†; Wang, D.; Sun, Y.; Ren, M.; Wang, Y.; Cao, X.; Zhang, L.; Fang, Y.; Tan, X.; Lu, H.; Cai, J.; Lu, X*.; Zhang, K*. Bottlebrush Polymer- Conjugated Melittin Exhibits Enhanced Antitumor Activity and Better Safety Profile, ACS Appl. Mater. Interfaces, 2021. DOI:10. 1021/acsami.1c 14285.

24. Fang, Y.;Lu, X.; Wang, D.; Cai, J.; Wang, Y.; Chen, P.; Ren, M.; Lu, H.; Union, J.; Zhang, L.; Sun, Y.; Jia, F.; Kang, X.; Tan, X.; Zhang, K.* Spherical Nucleic Acids for Topical Treatment of Hyperpigmentation, J. Am. Chem. Soc. 2021, 143, 1296-1300.

【2020】

23. Lu, X.†; Miao, L.†; Gao, W.; Chen, Z.; McHugh, K.; Sun, Y.; Tochka, Z.; Tomasic, S.; Sadtler, K.; Hyacinthe, A.; Huang, Y.; Graf, T.; Hu, Q.; Sarmadi, M.; Langer, R.*; Anderson, D.*; Jaklenec, A.* Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy. Sci. Transl. Med. 2020, 12, eaaz6606.

22.Lu, X.†; Fu, H.†; Shih, K.-C.; Jia, F.; Sun, Y.; Wang, D.; Wang, Y.; Ekatan, S.; Nieh, M.-P.*; Lin, Y.*; Zhang, K.* DNA-mediated step-growth polymerization of bottlebrush macromonomers. J. Am. Chem. Soc. 2020, 142, 10297-10301.

21. Sarmadi, M.; Behrens, A.; McHugh, K.; Contreras, H.; Tochka, Z.; Lu, X.; Langer, R.*; Jaklenec, A.* Modeling, design, and machine learning-based framework for optimal injectability of microparticle-based drug formulations. Sci. Adv. 2020, 6, eabb6594.

【2019】

20. Wang, D.; Lin, J.; Jia, F.; Tan, X.; Wang, Y.; Sun, X.; Cao, X.; Che, F.; Lu, H.; Gao, X.; Shimkonis, J.C.; Nyoni, Z.; Lu, X.*; Zhang, K.* Bottlebrush-architectured poly (ethylene glycol) as an efficient vector for RNA interference in vivo. Sci. Adv. 2019, 5, eaav9322.

19. Anselmo, A.C.*; Xu, X.*; Buerkli, S.*; Zeng, Y.; Tang, W.; McHugh, K.J.; Behrens, A.M.; Rosenberg, E.; Duan, A.R.; Sugarman, J.L.; Zhuang, J.; Collins, J.; Lu, X.; Graf, T.; Tzeng, S.Y.; Rose, S.; Acolatse, S.; Nguyen, T.D.; Le, X.; Guerra, A.S.; Freed, L.E.; Weinstock, S.B.; Sears, C.B.; Nikolic, B.; Wood, L.; Welkhoff, P.A.; Oxley, J.D.; Moretti, D.; Zimmermann, M.B.; Langer, R.**; Jaklenec, A.** A heat-stable microparticle platform for oral micronutrient delivery. Sci. Transl. Med. 2019, 11, eaaw3680.

【2018】

18. Lu, X.; Zhang, K.* PEGylation of therapeutic oligonucleotides: From linear to highly branched PEG architectures. Nano, Res. 2018, 11, 5519-5534.

17. Li, Z.; Behrens, A.M.; Ginat, N.; Tzeng, S.Y.; Lu, X.; Sivan, S.; Langer, R.*; Jaklenec, A.* Biofilm-inspired encapsulation of probiotics for the treatment of complex infections. Adv. Mater. 2018, 1803925.

16. Li, H.; Zhang, B.;Lu, X.; Tan, X.; Jia, F.; Xiao, Y.; Cheng, Z.; Li, Y.; Sliva, D.O.; Schrekker, H.S.; Zhang, K.; Mirkin, C.A. Molecular spherical nucleic acids. P. Natl. Acad. Sci. USA 2018, 115, 4340-4344.

15. Jia, F.; Wang, D.; Lu, X.; Tan, X.; Wang, Y.; Lu, H.; Zhang, K. Improving the enzymatic stability and the pharmacokinetics of oligonucleotides via DNA-backboned bottlebrush polymers. Nano Lett. 2018, 18, 7378-7382.

【2017年及以前】

14. Cao, X.†; Lu, X.†; Wang, D.; Jia, F.; Tan, X.; Corley, M.; Chen, X.; Zhang, K.* Modulating the cellular immune response of oligonucleotides by brush polymer-assisted compaction. Small 2017, 13, 1701432.

13. Wang, D.;Lu, X.; Jia, F.; Tan, X.; Sun, X.; Cao, X.; Wai, F.; Zhang, C.*; Zhang, K.* Precision Tuning of DNA-and  poly(ethylene glycol)-based nanoparticles via co-assembly  for effective antisense gene regulation. Chem. Mater. 2017, 29, 9882-9886.

12. Jia, F.; Lu, X.; Wang, D.; Cao, X.; Tan, X.; Lu, H.; Zhang, K.* Depth-profiling the nuclease stability and the gene silencing efficacy of  brush-architectured poly 

 (ethylene glycol)-DNA conjugates. J. Am. Chem. Soc. 2017, 139, 10605-10608.

11. Jia, F.; Lu, X.; Tan, X.; Wang, D.; Cao, X.; Zhang, K.* Effect of PEG Architecture on the hybridization thermodynamics and protein accessibility of PEGylated oligonucleotides. Angew. Chem. Int. Ed. 2017, 56, 1239-1243.

10. Cressiot, B.; Greive, S.J.; Si, W.; Pascoa, T.; Mojtabavi, M.; Chechik, M.; Jenkins, H.T.; Lu, X.; Zhang, K.; Aksimentiev, A.*; Antson, A.A.*; Wanunu, M.* Porphyrin-Assisted docking of a thermophage portal protein into lipid bilayers:  nanopore engineering and  characterization. ACS Nano 2017, 11, 11931-11945.

9. Antczak, N.M.; Packer, M.R.; Lu, X.; Zhang, K.; Beuning, P.J.* Human Y-family DNA polymerase kappa is more tolerant to changes in its active site loop than its ortholog Escherichia coli Dinb.Chem. Res. Toxicaol. 2017, 30, 2002-2012.

8. Tan, X.; Lu, X.; Jia, F.; Liu, X.; Sun, Y.; Logan, J.K.; Zhang, K.* Blurring the role of oligonucleotides: spherical nucleic acids as a drug delivery vehicle. J. Am. Chem. Soc. 2016, 138, 10834-10837.

7.  Lu, X.; Jia, F.; Tan, X.; Wang, D.; Cao, X.; Zheng, J.; Zhang, K.* Effective antisense gene regulation via non-cationic, polyethylene glycol brushes.J. Am. Chem. Soc. 2016, 138, 9097-9100.

6. Lu, X.; Tran, T.H.; Jia, F.; Tan, X.; Davis, S.; Krishnan, S.; Amiji, M.M.; Zhang, K.* Providing oligonucleotides with steric selectivity by brush polymer-assisted compaction. J. Am. Chem. Soc. 2015, 137, 12466-12469.

5. Tan, X.; Li, B.B.; Lu, X.; Jia, F.; Santori, C.; Menon, P.; Li, H.; Zhang, B.; Zhao, J.J; Zhang, K.* Light-triggered, self-immolative nucleic acid-drug nanostructures.J. Am. Chem. Soc. 2015, 137, 6112-6115.

4. Nevin, P.;Lu, X.; Zhang, K.; Engen, J.; Beuning, P. Non-cognate DNA damage prevents formation of active conformation of Y-family DNA polymerases DinB and pol kappa. Faseb J. 2015, 29, 2646.

3. Jia, F.;Lu, X.; Tan, X.; Zhang, K.* Facile synthesis of nucleic acid-polymer amphiphiles and their self-assembly. Chem. Commun. 2015, 51, 7843-7846.

2. Lu, X.; Watts, E.; Jia, F.; Tan, X.; Zhang, K.* Polycondensation of polymer brushes via DNA hybridization. J. Am. Chem. Soc. 2014, 136, 10214-10217.

1. Lu, X.; Xu. J.* Negative ion mass spectral fragmentation of N-alkoxycarbonyl-1-aminoarylmethyl phosphonic monoesters under electrospray ionization conditions. Phosphorus, Sulfur, Silicon Relat. Elem. 2012, 187, 1151-1160.